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In six stud-ies with 994 subjects with mild-to-moderate AD, signifi -cant improvement occurred in one trial with the largestsample size.

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Is discharge from the eyes or nose present? Are the eyes “sunken in”?Determine capillary refill time (CRT) by lifting the patient’s lip and pressing on a sectionof pink gingiva.

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There is a need for high- qualityRCTs to delineate the range of delivered pressurefor a given ?ow, for all sizes of preterm infants.Until the results of these trials are available, ifan infant requires CPAP, then it can more safelybe delivered with a standard device (Davis et al.2009; So et al.